Showing results for: "cellular signalling" (51 results)
Cells constantly sense signals from their environment and convert them into internal actions through biochemical signalling pathways.
Cells can be understood as highly coordinated systems in which DNA functions as a comprehensive but inert blueprint, requiring precise interpretation to become biologically active. Gene expression depends on regulatory proteins that orchestrate transcription across time and space.
How the fruit fly egg chamber reveals the secrets of cell migration and offers powerful insights into cancer metastasis and future therapies.
Tiny but powerful, basement membranes support cells, regulate barriers, and drive disease when disrupted—key players in health, aging, and cancer.
Discover how the SNAP29 gene guides cellular traffic, and how its mutation leads to CEDNIK syndrome, affecting brain, nerves, and skin.
Explore the multi-organ cellular mapping of GLP-1 receptor agonists. Discover how GLP-1RAs act as a systemic shield across T2DM, obesity, PMOS, MASH and so on.
The current trajectory of epilepsy management has encountered a formidable "refractory wall." Despite the accelerated expansion of the neuropharmacological pharmacopeia,
The tumor microenvironment (TME) is a complex and dynamic ecosystem composed of malignant cells, immune infiltrates, stromal elements, and vascular components that collectively influence tumor initiation, progression, immune escape, and therapeutic response. Traditional bulk transcriptomic approaches obscure this complexity by averaging gene expression across heterogeneous cell populations.
Ageing is accompanied by a gradual decline in physiological functions, among which deterioration of the immune system termed immunosenescence—has profound implications for human health.
Wound healing is a complex and dynamic biological process that occurs through four overlapping phases: hemostasis, inflammation, proliferation, and maturation. To repair tissue damage, the body works intensively, thereby significantly increasing cellular metabolic demands.
Disorders of Gut–Brain Interaction (DGBIs), such as Functional Dyspepsia (FD) and Irritable Bowel Syndrome (IBS), present a formidable clinical impasse due to their profoundly heterogeneous and multifactorial nature.
This architecture is essential for shielding neurons from toxins, pathogens, and fluctuations in the bloodstream, but it also creates a devastating bottleneck for modern medicine. More than 98% of small-molecule drugs and nearly all large biological therapeutics fail to cross the BBB in meaningful amounts, leaving many promising treatments for neurodegenerative disorders, brain tumors, and inflammatory diseases stranded in the circulation.
Discover how antigen-presenting cells like dendritic cells and macrophages are being recruited through smart particle design for vaccines and immunotherapy.
The human ear is often described as one of the most sophisticated sensory systems in biology. Within a structure no larger than a seashell, the auditory system can detect frequencies ranging from the faint rumble of distant thunder to the subtle harmonic texture of a violin string
Imagine being able to control a computer, a prosthetic limb, or even a drone just by using your thoughts. This is not science fiction; it is now a reality thanks to brain-computer interfaces (BCIs). BCIs are groundbreaking systems that enable direct communication between the brain and external devices.
Animal models have traditionally served as the cornerstone of drug safety evaluation; however, major translational challenges persist due to interspecies differences in physiology, metabolism, and genetic regulation. Many compounds demonstrating favorable toxicity profiles in animals later fail during human trials or are withdrawn post-marketing due to unforeseen adverse effects, especially hepatotoxicity and cardiotoxicity (Lee et al., 2025).
Learn how the leading cause of death worldwide activates the immune system and how making a few lifestyle changes can decrease your risk of severe chronic disease.
Inhalable vaccines trigger powerful mucosal immunity where pathogens enter the body, offering needle-free protection against respiratory diseases.
What does stress actually do to your body? Explore the neurobiology of the survival response, from the immediate SAM axis to the the HPA axis, and learn how to restore your biological equilibrium.
Ever wonder what it’s like if a tiny chip could detect cancer before symptoms appear. Biosensor technology is transforming cancer detection- earlier, faster and more accessible for people worldwide
